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目的 探讨脑室镜辅助颅内动脉瘤夹闭术联合急性高容量血液稀释对早期脑动脉瘤患者血清S100B蛋白、血清基质金属蛋白酶-9水平及生活质量的影响.方法 将87例早期脑动脉瘤患者按照随机数字表法分为两组,两组均给予脑室镜下颅内动脉瘤夹闭术治疗,观察组联合急性高容量血液稀释治疗.比较两组的夹闭效果、手术前后血清S100B及血清基质金属蛋白酶-9水平,比较两组并发症发生情况,于手术前后采用生活质量量表评定两组患者的生活质量.结果 观察组夹闭良好率为88.6％,对照组为65.1％,观察组显著高于对照组(P＜0.05).手术后3 d起两组血清基质金属蛋白酶-9水平均较手术前显著持续降低(P＜0.01),观察组显著低于对照组(P＜0.01);手术后3 d观察组S100B蛋白水平显著高于手术前(P＜0.01),且显著高于对照组(P＜0.01).观察组并发症发生率显著低于对照组(P＜0.05).手术后3个月两组生活质量量表评分均显著高于手术前(P＜0.01),观察组显著高于对照组(P＜0.01).结论 脑室镜辅助颅内动脉瘤夹闭术联合急性高容量血液稀释治疗早期脑动脉瘤患者效果显著,可显著改善患者血清基质金属蛋白酶-9的水平及生活质量,并发症发生率低,值得推广应用.“,”Objective To investigate the effects of clipping of intracranial aneurysm assisted with ventriculoscope combined with hypervolemic hemodilution on serum S100B protein, MMP-9 level and life quality in patients with early cerebral aneurysm. Methods 87 cases of patients with early cerebral aneurysm were randomly divided into two groups, the two groups were all given clipping of intracranial aneurysm assisted with ventriculoscope, and the observation group was plus AHH. Clipping effect, serum S100B,MMP-9 levels, complication occurrence of the two groups were compared, QLQ was used to evaluate the life quality of patients before and after operation. Results Good rate of clipping in the observation group and the control group were 88.6％, 65.1 ％ respectively, and the observation group was significantly higher than the control group (P＜0.05). Since the third day after operation, serum MMP-9 level was significantly declined continuously compared with that before operation (P＜0.01), the observation group was significantly lower than the control group (P＜0.01); 3d after operation, S100B protein level in the observation group was significantly higher than that before operation (P＜0.01),and was significantly higher than that in the control group (P＜0.01). Complication incidence rate of the observation group was significantly lower than that of the control group (P＜0.05).3 months after operation, QLQ scores of the two groups were all significantly higher than those before operation (P＜0.01),and the observation group was significantly higher than the control group (P ＜0.01). Conclusion Clipping of intracranial aneurysm assisted with ventriculoscope combined with hypervolemic hemodilution in the treatment of patients with early cerebral aneurysm have remarkable curative effect, it can significantly improve serum MMP-9 level and life quality, with lower complication incidence rate,and it is worthy of wide application.