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目的观察PCI术(经皮冠状动脉介入治疗)后合并焦虑抑郁对患者内皮素-1(ET-1)和人纤溶酶原激活物抑制因子-1(PAI-1)浓度的影响,并分析PCI术后合并焦虑抑郁与ET-1、PAI-1之间的关系。方法采用ELISA法,对220例行PCI术患者经汉密尔顿焦虑抑郁评分分为有焦虑抑郁(介入术后观察组)和无焦虑抑郁(介入术后对照组),及85例未行PCI术治疗的冠心病患者(非介入组),进行血清ET-1、PAI-1含量的检测,并进行统计学分析。结果 PCI术患者血清ET-1及PAI-1水平明显高于非介入治疗的冠心病患者,且PCI术后合并焦虑抑郁患者血清ET-1、PAI-1浓度明显高于PCI术后没有焦虑抑郁的患者,差异具有显著性。结论 PCI术和焦虑抑郁状态均影响患者血浆ET-1及PAI-1水平。
Objective To observe the effect of combined treatment of anxiety and depression on the concentration of endothelin-1 (ET-1) and human plasminogen activator inhibitor-1 (PAI-1) in patients with PCI after percutaneous coronary intervention Relationship between anxiety, depression and ET-1, PAI-1 after PCI. Methods 220 patients undergoing PCI were divided into anxiety and depression (intervention group) and no anxiety and depression (intervention group after intervention) by ELISA, and 85 patients who did not receive PCI Patients with coronary heart disease (non-intervention group), serum ET-1, PAI-1 levels were detected and statistical analysis. Results The serum levels of ET-1 and PAI-1 in patients with PCI were significantly higher than those of non-intervention patients with coronary heart disease. The concentrations of ET-1 and PAI-1 in patients with anxiety and depression after PCI were significantly higher than those without PCI Of patients, the difference was significant. Conclusion Both PCI and anxiety and depression status affect the levels of plasma ET-1 and PAI-1 in patients.