论文部分内容阅读
目的:探讨膜联蛋白A2(ANXA2)在宫颈癌组织中的表达及其临床意义。方法:选择2010年1月～2011年1月在延边大学附属医院妇产科住院的宫颈癌患者56例作为研究对象,采用免疫组织化学方法检测宫颈癌、宫颈原位癌及正常宫颈组织中ANXA2的表达,并观察不同临床病理特征宫颈癌组织中ANXA2的表达情况。结果:ANXA2在宫颈癌、宫颈原位癌及正常宫颈组织中的阳性率分别为89.5%、56.8%及10.2%,各组间差异有统计学意义(P<0.05)。有淋巴结转移的宫颈癌组织中ANXA2的阳性表达较无淋巴结转移的宫颈癌组织中阳性率高,差异有统计学意义(P<0.05)。结论:ANXA2高表达与宫颈癌组织的发生发展及远处转移密切相关。
Objective: To investigate the expression of annexin A2 (ANXA2) in cervical cancer and its clinical significance. Methods: From January 2010 to January 2011, 56 cases of cervical cancer hospitalized in Obstetrics and Gynecology Hospital of Yanbian University were enrolled as the research object. Immunohistochemistry was used to detect the expression of ANXA2 in cervical cancer, cervical carcinoma in situ and normal cervical tissue The expression of ANXA2 in cervical cancer tissues with different clinicopathological features was observed. Results: The positive rates of ANXA2 in cervical cancer, cervical carcinoma in situ and normal cervical tissue were 89.5%, 56.8% and 10.2%, respectively, with significant difference (P <0.05). The positive rate of ANXA2 in cervical cancer tissues with lymph node metastasis was higher than that in cervical cancer without lymph node metastasis (P <0.05). Conclusion: The high expression of ANXA2 is closely related to the occurrence, development and distant metastasis of cervical cancer.