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有机阴离子转运体2(OAT2)属于有机阴离子转运体家族成员,主要分布于肝肾,介导肌酐、尿酸等内源性物质及多种外源性药物的跨膜转运。OAT2对外源性物质如药物的体内过程如吸收、分布、代谢和排泄过程起着重要作用。研究表明OAT2的表达与活性被药物、疾病、性别及基因多态性等多种因素影响,亦受到核受体等信号通路调控。故本文综述药物转运体OAT2的结构与分布、底物、调控机制、临床意义的研究进展,为OAT2可能介导药物相互作用及药物疗效预测提供参考。
Organic anion transporter 2 (OAT2) is a member of the organic anion transporter family, mainly in the liver and kidney, mediating the transmembrane transport of endogenous substances such as creatinine and uric acid and various exogenous drugs. OAT2 plays an important role in the in vivo processes of exogenous substances such as drugs such as absorption, distribution, metabolism and excretion. Studies have shown that the expression and activity of OAT2 are influenced by many factors such as drugs, diseases, gender and genetic polymorphisms, and are also regulated by nuclear receptors and other signaling pathways. This article reviews the structure and distribution of drug transporter OAT2, the substrate, regulatory mechanisms, clinical significance of the research, for OAT2 may mediate drug interactions and drug efficacy prediction.