论文部分内容阅读
家兔暴露于低压舱,每天4h,连续2周。第一周与第二周的模拟海拔高度分别为3800m和5000m。阶梯低氧适应后,适应组与急性低氧组家兔一同暴露于模拟海拔5000m,停留3h。暴露后家兔和正常对照家兔(n=5)均进行了电镜观察。结果发现,急性低氧兔肺毛细血管内皮明显肿胀,有时因毛细血管内皮明显隆出而使毛细血管腔变小。而在低氧适应组,肺毛细血管内皮肿胀程度减轻,同时也未见因内皮膨出而使毛细血管腔变小的现象。文章还讨论了本观察结果的生理意义。
Rabbits were exposed to the hypobaric chamber for 4 hours a day for 2 weeks. The first and second weeks of simulated altitude were 3800m and 5000m respectively. After the step hypoxia adaptation, the adaptive group and the acute hypoxia group were exposed to simulated altitude of 5000m and stayed for 3h. After exposure to rabbits and normal control rabbits (n = 5) were observed by electron microscopy. The results showed that acute hypoxic rabbit pulmonary capillary endothelial significantly swelling, capillary capillaries sometimes become smaller due to the prominent capillary endothelial. In the hypoxic adaptation group, the degree of pulmonary capillary endothelial swelling was reduced, and no phenomenon was found that the capillary lumen became smaller due to endothelial bulging. The article also discusses the physiological significance of this observation.