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目的 探讨非酒精性脂肪性肝病(NAFLD)患者血Leptin水平及其相关因素。方法 从本院收集 NAFLD的患者50例,其中男性组和女性组各25例,另收集了身体健康男性和女性各25例为对照组,测定体重指 数(BMI),腰臀围比,血空腹胰岛素和Leptin水平。结果 NAFLD两组血Leptin水平均较与之相对应的对照组明 显升高,四组血Leptin水平与BMI(r=0.360,P<0.05)、腰臀围比(r=0.376,P<0.05)和空腹胰岛素(r= 0.334,P<0.05)均呈正相关。女性组血Leptin水平比男性组约高1.5倍(P<0.05)。结论 NAFLD患者血 Leptin水平明显升高,NAFLD患者存在Leptin抵抗。
Objective To investigate the level of blood Leptin in non-alcoholic fatty liver disease (NAFLD) and its related factors. Methods Fifty patients with NAFLD were collected from our hospital, including 25 males and 25 females. Another 25 healthy males and 25 females were selected as the control group. Body mass index (BMI), waist-hip ratio Insulin and Leptin levels. Results Compared with the control group, the levels of Leptin in NAFLD group and BMI group were significantly higher than those in the control group (P <0.05). The ratio of waist-hip ratio (r = 0.376, P <0.05) And fasting insulin (r = 0.334, P <0.05) were positively correlated. Leptin levels were about 1.5 times higher in women than in men (P <0.05). Conclusions Leptin levels in NAFLD patients are significantly higher than those in NAFLD patients.