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目的:观察百令胶囊对糖尿病肾病肿瘤坏死因子-α(TNF-α)的影响。方法:将首次就诊的50例早期糖尿病肾病患者随机分为治疗组和对照组,每组各25例。两组患者均给予基础治疗(用人胰岛素控制血糖,贝那普利控制血压,糖尿病饮食),治疗组在此基础上加用百令胶囊,5粒,po,tid。疗程3个月。酶联免疫吸附法(ELISA)测定两组患者治疗前后TNF-α水平。结果:治疗3个月后,治疗组血清TNF-α水平较对照组水平明显下降(P<0.01)。结论:百令胶囊能降低TNF-α水平,延缓糖尿病肾病的发展。
Objective: To observe the effect of Bailing capsule on tumor necrosis factor-α (TNF-α) in diabetic nephropathy. Methods: 50 patients with early diabetic nephropathy were randomly divided into treatment group and control group, with 25 cases in each group. Two groups of patients were given basic treatment (insulin control blood glucose, benazepril controlled blood pressure, diabetes diet), the treatment group on this basis with Bailing capsule, 5, po, tid. Course of 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to determine the level of TNF-α in two groups before and after treatment. Results: After 3 months of treatment, the level of serum TNF-α in the treatment group was significantly lower than that in the control group (P <0.01). Conclusion: Bailing capsule can reduce the level of TNF-α, delay the development of diabetic nephropathy.