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目的 探讨吗啡能否促进大鼠受损伤的初级传入纤维终末在脊髓Ⅱ板层再生及其突触重建。 方法 采用电镜定量方法计数吗啡组、生理盐水组和纳络酮吗啡组坐骨神经损伤后 15d和 30d ,L4脊髓Ⅱ板层背根无髓传入纤维来源的Ⅰ型复合终末、背根有髓传入纤维来源的Ⅱ型复合终末和由中间神经元轴突和下行传导束轴突形成的简单终末。 结果 吗啡组大鼠脊髓Ⅱ板层的Ⅰ型复合终末数比生理盐水组和纳络酮吗啡组明显增多 ,然而 ,Ⅱ型复合终末却比生理盐水组和纳络酮吗啡组少。 3组大鼠脊髓Ⅱ板层的突触性终末总数 ,复合终末数和简单终末数没有差异。 结论 吗啡能够促进大鼠脊髓Ⅱ板层受损伤的初级无髓传入纤维终末再生及其突触重建 ,这可能通过阿片受体介导。
Objective To investigate whether morphine can promote the regeneration of primary lamina propria fibers and its synaptic reconstruction in spinal cord Ⅱ lamina propria in rats. Methods Electron microscopy quantitative counting of morphine group, saline group and naloxone morphine group after sciatic nerve injury 15d and 30d, L4 spinal cord layer Ⅱ lamina dorsal root into fiber-derived type Ⅰ composite terminal dorsal root marrow Into fiber-derived Type II composite termini and simple terminals formed by interneuron axons and descending fascicles. Results The number of type Ⅰ complex terminals in the spinal lamina Ⅱ in morphine group was significantly higher than that in saline group and naloxone morphine group. However, the type Ⅱ complex terminal number was less than that in saline group and naloxone morphine group. There was no difference in the total number of terminal synaptic terminals, complex terminal number and simple terminal number of the spinal cord II in the three groups. Conclusion Morphine can promote the regeneration of primary nonmyelofibrous fibers and its synaptic reconstruction in the injured layer of rat spinal cord Ⅱ, which may be mediated by opioid receptors.