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目的探讨脑钠钛在慢性心衰(CHF)中的浓度变化,评价其临床意义。方法选择确诊的CHF患者50例,为心衰组,另选45例同期本院体检健康成人作为对照组,所有入选者均进行血浆BNP及超声多普勒的检测。结果心力衰竭患者血浆脑钠肽(BNP)水平明显高于正常人,其升高与心力衰竭程度紧密相关,BNP水平主要与左室功能相关。结论 BNP水平是反映心功能受损的敏感指标,与心功能状态(NYHA)及心脏超声心动图心功能参数均有明显的相关性。
Objective To investigate the changes of brain natriuretic peptide in chronic heart failure (CHF) and evaluate its clinical significance. Methods Fifty patients with confirmed CHF were selected as heart failure group and 45 healthy adults as the control group in the same period. All the patients were tested by BNP and Doppler echocardiography. Results The plasma BNP level in patients with heart failure was significantly higher than that in normal people. The elevated BNP level was closely related to the degree of heart failure. The level of BNP was mainly associated with left ventricular function. Conclusions BNP level is a sensitive index to reflect the impaired cardiac function, which is significantly correlated with cardiac function parameters (NYHA) and cardiac echocardiography.