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目的研究脂肪肝在江门市新会区成人中的流行趋势、现状与危险因素。方法对3483各类体检人员的健康咨询、体格检查、空腹血糖、肝功能、血脂等指标及肝脏B超检查结果进行回顾性分析。结果江门市新会区体检人员中检出脂肪肝769例(22.08%),经年龄和性别调整后,新会区成人脂肪肝患病率21.57%。酒精性脂肪肝、可疑酒精性脂肪肝、非酒精性脂肪肝患病率分别为0.86%、0.69%、20.02%。脂肪肝患病率均随年龄增长而增加,60岁之前男性脂肪肝患病率显著高于女性,而60岁以后男女脂肪肝患病率相当。单因素分析显示,脂肪肝组年龄、体重指数、腰围、舒张压、空腹血糖、甘油三酯、胆固醇、丙氨酸氨基转移酶均显著高于非脂肪肝组(P<0.001)。多元回归分析显示:甘油三酯、腰围、空腹血糖、BMI、舒张压、丙氨酸氨基转移酶、年龄和性别(男性)等指标与脂肪肝密切相关。结论江门市新会区成人脂肪肝患病率高,主要为非酒精性脂肪肝。脂肪肝发病率男性明显高于女性。高脂血症、超重及肥胖、糖代谢紊乱、高血压、高丙氨酸氨基转移酶、年龄、男性等为脂肪肝危险因素。
Objective To study the prevalence, current status and risk factors of fatty liver in adults in Xinhui District of Jiangmen City. Methods A retrospective analysis was conducted on the health consultation, physical examination, fasting blood glucose, liver function, blood lipids and other liver biopsy findings of 3483 medical staff. Results 769 cases (22.08%) of fatty liver were detected in Xinhui District, Jiangmen City. The prevalence of fatty liver in Xinhui District was 21.57% after age and gender adjustment. Alcoholic fatty liver, suspicious alcoholic fatty liver, non-alcoholic fatty liver prevalence were 0.86%, 0.69%, 20.02%. The prevalence of fatty liver increased with age. The prevalence of fatty liver in men before 60 was significantly higher than that in women, while the prevalence of fatty liver was similar in men and women after 60 years of age. Univariate analysis showed that age, body mass index, waist circumference, diastolic blood pressure, fasting blood glucose, triglyceride, cholesterol and alanine aminotransferase in fatty liver group were significantly higher than those in non-fatty liver group (P <0.001). Multivariate regression analysis showed that triglyceride, waist circumference, fasting blood glucose, BMI, diastolic blood pressure, alanine aminotransferase, age and gender (male) were closely related to fatty liver. Conclusion The prevalence of fatty liver in Xinhui District of Jiangmen City is high, mainly of non-alcoholic fatty liver. The incidence of fatty liver was significantly higher in males than in females. Hyperlipidemia, overweight and obesity, disorders of glucose metabolism, hypertension, high alanine aminotransferase, age, males and other fatty liver risk factors.