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目的制备壳聚糖-乙二胺四乙酸(CTS-EDTA)纳米粒,通过动物实验观察壳聚糖-乙二胺四乙酸纳米粒(CEC-Nano)对放射性锶的促排效果尤其是预防性给药的促排效果。方法通过N-酰化反应连接壳聚糖与乙二胺四乙酸纳,并将反应产物与TPP利用离子凝胶法制成纳米粒。通过染毒前与染毒后给药,比较其治疗性与预防性促排效果。结果 CTS-EDTA纳米粒通过透射电镜观察显示可得到粒度较为均一的球形纳米粒子。体内实验表明,小鼠骨头尤其是颅骨的放射性锶含量在预防给药治疗组比对照组和即刻给药治疗组明显低(P<0.05),小鼠体内整体放射性锶残留量也比其他组明显低(P<0.05)。结论 CEC-Nano对体内放射性锶具有良好的促排效果尤其是预防性给药治疗促排效果更好。
OBJECTIVE To prepare chitosan-ethylenediaminetetraacetic acid (CTS-EDTA) nanoparticles and observe the promoting effect of chitosan-ethylenediaminetetraacetic acid nanoparticles (CEC-Nano) on the radioactive strontium by animal experiments, especially the prophylactic Promote the effect of drug delivery. Methods The chitosan and ethylenediaminetetraacetic acid were connected by N-acylation reaction, and the reaction product and TPP were made into nanoparticles by ion-gel method. Pre-exposure and post-exposure administration, compared with the therapeutic and preventive effect of promoting the emission. Results The CTS-EDTA nanoparticles showed that the spherical nanoparticles with uniform particle size could be obtained by transmission electron microscopy. In vivo experiments showed that the radioactive strontium content of mice bones, especially the skull, was significantly lower (P <0.05) in the prophylaxis-treated group than in the control group and the immediate administration group, and the whole radioactive strontium residue in the mice was also significantly more than the other groups Low (P <0.05). Conclusions CEC-Nano has a good effect on promoting the in vivo radioactive strontium, especially the prophylactic drug treatment.