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目的:探讨使用游离皮瓣修复晚期颅底肿瘤术后缺损组织的效果及适应症。方法:选择2009年1月至2013年9月在我院行晚期颅底肿瘤术并且需要进行组织修复的病患74例作为研究对象。根据病患选择的修复方式分为观察组和对照组各37例。观察组采用游离皮瓣,而对照组使用钛网修复。观察两组相应指标,比较不同修复材料的修复效果。结果:观察组手术效果显效率和总有效率为40.54%(15/37)、97.30%(36/37),显著高于对照组,差异有统计学意义(P<0.05)。观察组在术中出血量、手术时间以及术后愈合时间等方面均优于对照组,差异有统计学意义(P<0.05)。观察组术后出现颅内感染、脑脊液漏和皮瓣坏死比率为8.11%(3/37)、0(0/37)和2.70%(1/37)都少于对照组,差异有统计学意义(P<0.05)。结论:采用前臂皮瓣进行晚期颅底肿瘤术后缺损组织修复效果更好,皮瓣存活率更高。比传统钛网修复引起的并发症更少,值得临床推荐使用。
Objective: To investigate the effect and indications of using free flap to repair postoperative defect of skull base tumor. Methods: From January 2009 to September 2013 in our hospital advanced cranial tumors and 74 cases of patients need to be repaired tissue as the research object. According to the patient’s choice of repair methods were divided into observation group and control group of 37 cases. The observation group with free flap, while the control group using titanium mesh repair. The corresponding indicators of two groups were observed, and the repair effects of different repair materials were compared. Results: The effective rate and total effective rate of the observation group were 40.54% (15/37) and 97.30% (36/37), respectively, which were significantly higher than those of the control group (P <0.05). The observation group was better than the control group in the amount of bleeding, operation time and postoperative healing time, the difference was statistically significant (P <0.05). The incidence of intracranial infection in the observation group was 8.11% (3/37), 0 (0/37) and 2.70% (1/37) respectively in the observation group, with a statistically significant difference (P <0.05). Conclusion: Forearm flap is more effective for postoperative defect repair of skull base tumor and the flap survival rate is higher. Than the traditional titanium mesh repair caused fewer complications, it is recommended for clinical use.