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目的观察高胆红素血症新生儿γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)和总胆汁酸(TBA)水平的变化情况,对各血清酶代谢异常的临床意义进行探讨。方法选取2013年10月-2015年5月于平凉市第二人民医院收治的高胆红素血症新生儿120例作为观察组,根据患儿总胆红素(TBil)水平将其分别为轻度组、中度组与重度组,另选取同期收治的健康新生儿40例作为对照组。分别检测并比较各组新生儿GGT、ALP、AST、LDH、TBA等血清酶水平。结果与对照组比较,观察组患儿的GGT、ALP、AST、LDH、TBA水平均显著增高(P<0.05),且轻度组、中度组与重度组患儿的GGT、ALP、AST、LDH、TBA水平呈逐渐升高的趋势,各组间比较差异均有统计学意义(P<0.05);与治疗前比较,观察组患儿治疗后其GGT、ALP、AST、LDH、TBA水平均明显降低,差异均具有显著性(P<0.05)。结论新生儿在患有高胆红素血症时,其GGT、ALP、AST、LDH、TBA水平均明显升高,能够用于该疾病引起的肝功能及心肌损伤的检测,临床上应针对检测结果及时给予治疗,以有效恢复患儿健康。
Objective To observe the levels of GGT, ALP, AST, LDH and TBA in neonates with hyperbilirubinemia. The clinical significance of the abnormal metabolism of serum enzymes were discussed. Methods A total of 120 neonates with hyperbilirubinaemia who were admitted to the Second People’s Hospital of Pingliang City from October 2013 to May 2015 were selected as the observation group. According to the level of total bilirubin (TBil) Degree group, moderate group and severe group. Another 40 healthy newborns were selected as the control group. The levels of GGT, ALP, AST, LDH, TBA and other serum enzymes in neonates were detected and compared. Results Compared with the control group, the levels of GGT, ALP, AST, LDH and TBA in the observation group were significantly increased (P <0.05). The levels of GGT, ALP, AST, (P <0.05). Compared with those before treatment, the levels of GGT, ALP, AST, LDH and TBA in the observation group were all significantly increased Significantly lower, the difference was significant (P <0.05). Conclusion Newborns with hyperbilirubinemia, GGT, ALP, AST, LDH, TBA levels were significantly increased, can be used for the detection of liver function and myocardial damage caused by the disease, the clinical should be tested The results of timely treatment, in order to effectively restore children’s health.