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目的:观察泮托拉唑与莫沙必利联合治疗反流性食管炎临床效果。方法:将80例经内镜确诊的胃食管反流病患者随机分为治疗组和对照组,治疗组给予泮托拉唑40 mg,1次/d口服,莫沙必利5 mg,3次/d口服,对照组给予法莫替丁20 mg,2次/d口服莫沙必利5 mg,3次/d口服,治疗8 w后对两组的临床疗效及产生的副作用差异进行对比观察,比较两组的有效率。结果:两组临床症状改善的总有效率分别为95.1%和75.2%(P均<0.05),两组均未见严重不良反应。结论:泮托拉唑与莫沙必利联合治疗老年胃食管反流病疗效显著,可在临床工作中借鉴应用。
Objective: To observe the clinical effect of pantoprazole and mosapride in the treatment of reflux esophagitis. Methods: Eighty patients with gastroesophageal reflux disease diagnosed by endoscopy were randomly divided into treatment group and control group. The treatment group was given pantoprazole 40 mg orally once daily, mosapride 5 mg, / d orally, the control group was given famotidine 20 mg, 2 times / d orally taken mosapride 5 mg, 3 times / d orally, after 8 weeks of treatment of the two groups were compared the clinical efficacy and side effects , Comparing the efficiency of the two groups. Results: The total effective rates of clinical symptom improvement in two groups were 95.1% and 75.2% respectively (all P <0.05), and no serious adverse reactions were found in both groups. Conclusion: The combination of pantoprazole and mosapride in the treatment of geriatric gastroesophageal reflux disease has a significant effect and can be used in clinical practice.