论文部分内容阅读
目的 观察脑苷肌肽对新生儿缺氧缺血性脑病 (HIE)治疗效果。方法 将足月HIE新生儿随机分为A、B两组 ,A组在常规综合治疗的基础上加用脑苷肌肽 ,B组给予常规综合治疗。生后 5d内、发病后 15～ 2 5d、90～ 12 0d行头颅CT平扫 ,发病后 15～ 2 5d行新生儿行为神经测定 (NBNA)。结果 A组在近期疗效评定、头颅CT恢复程度、NBNA测定等方面明显优于B组 (χ2 =5 .6 1,P <0 .0 5 ;χ2=6 .4 2 ,P<0 .0 5 ;t1=6 .18,t2 =8.36 ,Ps<0 .0 1)。结论 脑苷肌肽对降低HIE病儿的死亡率、伤残率及促进中枢神经系统功能恢复有着明显作用。
Objective To observe the effect of cerebroside on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Newborn infants with full-term HIE were randomly divided into A and B groups. Group A received CGS on the basis of conventional comprehensive treatment and group B received conventional comprehensive treatment. Within 5 days after birth, 15 to 25 days after onset, cranial CT scan from 90 to 120 days after onset, and neonatal behavioral nerve assay (NBNA) from 15 to 25 days after onset. Results A group was significantly better than B group in evaluation of curative effect, degree of head CT recovery and NBNA measurement (χ2 = 5.61, P <0.05; χ2 = 6.24, P <0.05 ; t1 = 6.18, t2 = 8.36, Ps <0.01). Conclusion Cerebroside can reduce the mortality, disability rate and promote the recovery of central nervous system function in children with HIE.