【摘 要】
：
Diabetic neuropathy is a disorder which affects various regions of the nervous sys-tem and there is no specific treatment available for it. So, the present study eval-uated protective effect of molsidomine in diabetic neuropathy in rats. Diabetes was indu
【机 构】
：
Pharmacology Department and Al-Ameen College of Pharmacy and Rajiv Gandhi University,Bangalore,India
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Diabetic neuropathy is a disorder which affects various regions of the nervous sys-tem and there is no specific treatment available for it. So, the present study eval-uated protective effect of molsidomine in diabetic neuropathy in rats. Diabetes was induced in male Wistar rats by administrating streptozotocin (52 mg/kg i.p). Diabetic rats were administered with molsidomine 5 mg/kg p.o, and 10mg/kg p.o. as treatment. After 8 weeks of treatment, Motor coordination, Mechanical allodynia, Mechanical hyperalgesia, Nerve conduction velocity, Glycosylated hemoglobin were assessed. Thereafter animals were sacrificed and sciatic nerve was isolated. It was used for reduced glutathione, lipid peroxidation and for histopathology. Treatment with molsidomine significantly improved motor coordination, paw withdrawal threshold, mechanical threshold and nerve conduction velocity. Furthermore, mol-sidomine treatment also reduced malondialdehyde levels and prevented depletion of reduced glutathione in sciatic nerve homogenate. Histopathology shows molsid-omine treatment maintained normal architecture of sciatic nerve. The results of our study strengthens the alterative use of molsidomine in diabetic neuropathy.
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