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自噬是亚细胞水平上细胞发生自我吞噬的过程,是双层膜结构的溶酶体与自噬囊泡融合成自噬溶酶体,降解泡内细胞质、器,释放氨基酸及游离脂肪酸,实现细胞自身代谢和细胞器更新,维持机体内环境稳定状态的过程,当细胞受到外界多种刺激(如缺乏营养、缺乏氧气、辐射、药品等)时均可诱发细胞自噬.自噬活性的改变及自噬信号通路和转运途径的负向调控与多种肿瘤的发生、发展密切相关,自噬基因的异常表达可启动或抑制某些肿瘤的形成[1],而Bec-
Autophagy is a process in which cells self-phagocytose at the subcellular level. It is a lysosome that fuses with the autophagic vesicles in a bilayer membrane structure. It degrades cytoplasm and vesicles in the cell and releases amino acids and free fatty acids. The process of cell metabolism and organelle renewal and the maintenance of environmental stability in the body can induce autophagy, change in autophagic activity and activity when cells are exposed to various external stimuli (such as lack of nutrients, lack of oxygen, radiation, drugs, etc.). The negative regulation of autophagy signaling pathway and transport pathway is closely related to the occurrence and development of various tumors. Abnormal expression of autophagy genes can initiate or inhibit the formation of certain tumors [1], while Bec-