二硫键氧化还原酶类似蛋白(DsbA-L)是一个最近发现的与脂联素相互作用的关键蛋白,它具有明显上调高相对分子质量脂联素水平及增强胰岛素敏感性的重要功能。DsbA-L水平与肥胖症以及内质网应激呈负相关,并能缓解由内质网应激诱导的脂联素水平下降。因此,DsbA-L是一个具有广泛前途的药物新靶点,而有效地调节DsbA-L的表达可能为治疗各种代谢疾病提供一个新的途径。 Disulfide-oxidoreductase-like protein (DsbA-L) is a recently discovered key protein that interacts with adiponectin and has important functions of up-regulating the level of adiponectin relative to its molecular weight and enhancing insulin sensitivity. DsbA-L levels were negatively correlated with obesity and endoplasmic reticulum stress, and could alleviate the decrease in adiponectin levels induced by endoplasmic reticulum stress. Therefore, DsbA-L is a promising new drug target. To effectively regulate the expression of DsbA-L may provide a new approach for the treatment of various metabolic diseases.