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目的探讨载脂蛋白（Ａｐｏ）Ｅ基因多态性与动脉粥样硬化性脑梗塞（ＡＣＩ）的关系。方法用聚合酶链反应（ＰＣＲ）技术检测了中国沈阳籍汉族健康人１００名和ＡＣＩ患者４７例的ＡｐｏＥ基因ＨｈａＩ多态性及血脂、脂蛋白含量。结果ＡＣＩ患者组ＡｐｏＥ基因型ε３／４的频率为２７．７％，明显高于对照组。ＡＣＩ患者组血清低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、脂蛋白（ａ）［Ｌｐ（ａ）］明显高于对照组，ＡｐｏＡＩ则明显低于对照组。对照组和ＡＣＩ患者组中ＡｐｏＥ基因型ε３／４的血清ＬＤＬ－Ｃ均显著高于ε３／３。结论ＡｐｏＥ基因型ε３／４与ＡＣＩ的发生相关；等位基因ε４可能是ＡＣＩ的一种遗传易感性因子。
Objective To investigate the relationship between apolipoprotein (Apo) E gene polymorphism and atherosclerotic cerebral infarction (ACI). Methods Polymerase chain reaction (PCR) technique was used to detect Hap I polymorphisms and lipids and lipoproteins of ApoE gene in 100 Han healthy subjects and 47 ACI patients in Shenyang, China. Results The frequency of ε3 / 4 in ApoE genotype was 27.7% in ACI group, which was significantly higher than that in control group. Serum low density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp (a)] were significantly higher in ACI patients than those in control group, and ApoAI was significantly lower than that in control group. Serum LDL-C of ApoE genotypes ε3 / 4 in both control and ACI patients was significantly higher than ε3 / 3. Conclusion The ApoE genotype ε3 / 4 is associated with the occurrence of ACI. The allele ε4 may be a genetic predisposition to ACI.