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目的：探讨巴曲酶对单侧颞叶缺血性损害大鼠空间认知加工能力的改善作用及与ＰＤＧＦ表达的关系。方法：用Ｍｏｒｉｓ迷宫监测大鼠空间认知能力，行为。实验结束后取脑进行梗死体积测定及ＰＤＧＦ免疫组化分析。结果：（１）、巴曲酶可以显著地缩短梗死大鼠在Ｍｏｒｉｓ迷宫中搜索目标的平均反应时和行程；（２）、巴曲酶组大鼠较多、较早地使用了正常的认知策略。巴曲酶治疗组颞叶梗死体积较单纯梗死组显著缩小，ＰＤＧＦＡ表达明显减少。结论：提示巴曲酶对单侧颞叶梗死大鼠空间认知功能障碍确有改善作用，其物质基础是巴曲酶减小了梗死体积，ＰＤＧＦＡ表达与颞叶损害有关联。
Objective: To investigate the effect of batroxobin on the spatial cognition of unilateral temporal lobe ischemic injury and its relationship with the expression of PDGF. Methods: The spatial cognition and behavior of rats were monitored by Moris maze. After the experiment, brain volume was measured and PDGF immunohistochemistry was performed. Results: (1) Batroxobin significantly shortened the average response time and stroke of the infarcted rats searching for the target in the Moris maze; (2) Batroxobin group had more rats and used earlier normal recognition Known strategy. Compared with simple infarction group, the volume of temporal lobe infarction in Batroxobin group was significantly reduced, and the expression of PDGFA was significantly reduced. Conclusion: It is suggested that batroxobin can improve the spatial cognitive dysfunction in rats with unilateral temporal lobe infarction. The substance basis is that batroxobin reduces infarct volume, and PDGFA expression is associated with temporal lobe damage.