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中药复方在临床中广泛应用,循证医学对中药复方研究提出新的挑战。开展中药复方的研究和开发,提供充足的疗效证据,以促进中医药现代化。本文提出中药复方循证生物系统研究策略(Chinese herbal compound formula evidencebased biosystem research strategy,CHCF-EB-BRS),从中医古医籍、系统评价、质量控制、临床辩证治疗疗效评价、物质基础及其作用机制等多层次对中药复方进行研究,从古医籍、系统评价和临床研究多层面验证中药复方的临床疗效,采用质量控制良好的复方进行实验室及临床研究,揭示复方的疗效物质基础及其作用机制,为解决目前中药复方研究面临的瓶颈提供参考。本策略各个研究层次已经在基础及临床研究中广泛实施,但仍缺乏某个中药复方系统性研究的案例,CHCF-EB-BRS思路的提出有助于系统深入研究中药复方,进一步促进中医药的发展。
Traditional Chinese medicine is widely used in clinical practice, and evidence-based medicine poses new challenges to the research of traditional Chinese medicine compound. To carry out research and development of traditional Chinese medicine compounds to provide sufficient evidence of efficacy to promote the modernization of Chinese medicine. In this paper, the Chinese herbal compound formula evidence based biosystem research strategy (CHCF-EB-BRS) is proposed from the aspects of ancient Chinese medicine, systematic evaluation, quality control, evaluation of clinical dialectical treatment efficacy, material basis and its mechanism of action And other multi-level study of traditional Chinese medicine compound, from the ancient medical books, systematic reviews and clinical studies to verify the clinical efficacy of traditional Chinese medicine compound, the use of good quality controlled compound laboratory and clinical studies to reveal the efficacy of the compound material basis and mechanism , To provide a reference for solving the bottleneck in the study of Chinese traditional medicine compound. The various research levels of this strategy have been widely implemented in basic and clinical studies. However, there is still a lack of systematic research on a Chinese herbal compound. The proposal of CHCF-EB-BRS will help to systematically study Chinese herbal compound and further promote the development of traditional Chinese medicine development of.