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目的：观察羧乙基锗倍半氧化物（ＣＧＳ）对大鼠实验性心肌缺血再灌注损伤的影响。方法：采用结扎大鼠冠状动脉３０ｍｉｎ后再通６０ｍｉｎ造成心肌缺血再灌注损伤模型，测定动脉血压，心律失常发生率，心律失常严重指数（ＡＳＩ），心肌组织中丙二醛（ＭＤＡ）含量，超氧化物歧化酶（ＳＯＤ）及ＡＴＰａｓｅ活性，血清中乳酸脱氢酶（ＬＤＨ）的水平等指标。结果：预防性静注ＣＧＳ（５０ｍｇ／ｋｇ）可显著降低再灌注心律失常发生率，心肌组织中ＭＤＡ和血清中ＬＤＨ的水平；明显改善再灌注后动脉血压的下降，心肌组织中ＳＯＤ及ＡＴＰａｓｅ活性的降低。结论：ＣＧＳ对大鼠实验性心肌缺血再灌注损伤具有保护作用
Objective: To observe the effect of carboxyethyl germanium sesquioxide (CGS) on experimental myocardial ischemia-reperfusion injury in rats. Methods: Myocardial ischemia-reperfusion injury was induced by ligating the coronary artery of rats for 30min and then for 60min. The arterial blood pressure, the incidence of arrhythmia, the severity of arrhythmia (ASI), the content of malondialdehyde (MDA) Superoxide dismutase (SOD) and ATPase activity, serum lactate dehydrogenase (LDH) levels and other indicators. Results: Preventive intravenous CGS (50mg / kg) significantly reduced the incidence of reperfusion arrhythmia, the levels of MDA and LDH in serum, decreased the arterial blood pressure and the activity of SOD and ATPase in myocardium The reduction. Conclusion: CGS has a protective effect on experimental myocardial ischemia-reperfusion injury in rats