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目的了解广西北部湾地区人群非缺失型α地贫等位基因携带者血液学数据变化情况。方法采用Gap-PCR、PCR-RDB法对799例受测者进行分析,并对受测者MCV、MCH和Hb值进行测定。结果αQSα等位基因对携带者血液学数据影响最重,αCSα等位基因对携带者血液学数据影响与αQSα类似,αWestmeadα的影响最轻。非缺失型α地贫等位基因与--SEA或--THAI等位基因杂合,均可引发Hb H病。结论αTα等位基因携带者的MCV值或者MCH值整体比野生型个体低,因此在日常筛查活动中,我们应密切留意受检者的MCV值和MCH值,以提示疑似携带者做进一步基因检测。
Objective To understand the changes of hematological data in carriers of non-deletional α-thalassemia population in Beibu Gulf, Guangxi. Methods 799 subjects were analyzed by Gap-PCR and PCR-RDB, and the MCV, MCH and Hb values were measured. Results αQSα allele had the greatest impact on carriers ’hematology data. ΑCSα allele had similar effect on carriers’ hematological data as αQSα, but αWestmeadα had the least effect. Non-deletional α-thalassemia alleles heterozygous with - SEA or - THAI alleles can cause Hb H disease. Conclusion The carriers of αTα allele have lower overall MCV or MCH values than wild type individuals, so we should pay close attention to subjects’ MCV and MCH values during routine screening activities to remind suspected carriers of further genes Detection.