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目的观察高同型半胱氨酸(Hcy)血症的2型糖尿病颈动脉粥样硬化患者补充叶酸(FA)、甲钴胺、维生素B6(VitB6)对高Hcy血症的影响。方法150例伴高Hcy血症的2型糖尿病颈动脉粥样硬化患者随机分为A组(叶酸组)；B组(叶酸+甲钴胺+维生素B6)和对照组。测定血浆Hcy、FA、VitB12、HbA1c、空腹血糖(FBG)、餐后2h血糖(PBG)、胆固醇(CHO)、甘油三脂(TG)、治疗4w后再次测定血浆Hcy的浓度。结果伴高Hcy血症的2型糖尿病颈动脉粥样硬化患者治疗前一般情况和生化指标及Hcy、TGF-？1、水平三组间无差异,治疗后,2个治疗组Hcy明显下降。 B组与A组相比,B组降Hcy最显著。结论补充叶酸、甲钴胺、维生素B6可降低血浆Hcy的水平。“,”Objective To clarify the ef ects of supplementation of folate (FA),methylcobalamin and vitamin-B6 on the hiperhomocysteinemia.Methods 150 cases of type 2 diabetes mel itus concomitant hiperhomocysteinemia were divided into 3 groups:folate group,B group (folate,methylcobalamin and vitmanin-B6)and control group.Plasma Hcy,FA,VitB12,HbA1c,FBG,PBG,CHO,TG,levels were measured.Plasma Hcy levels was measured after four weeks of treatment.Results Before treatment there was no dif erence on the levels of Hcy and biochemical data,but after treatment the levels on Hcy was significant decreased among 2 treatment groups.The B group had lower Hcy levels than that of control group.Conclusion Supplementation of folate,methylcobalamin and vitamin-B6 may reduce the plasma Hcy levels.