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目的分析咪达普利和缬沙坦联合治疗对原发性高血压患者左心室肥厚的逆转作用。方法选取本院于2014年2月—2015年2月期间入院的、接受左心室肥厚治疗的原发性高血压患者77例,随机分组,一组单纯使用咪达普利进行治疗(参照组,共有38例),而另一组使用咪达普利和缬沙坦联合治疗(研究组,共有39例)。其中参照组服用咪达普利10 mg/d,依据患者的病情变化进行调整。以10 mg/d的咪达普利以及80 mg/d的缬沙坦对研究组患者进行治疗,依据患者的病情变化进行调整。观察患者的LVMI、心率、肌酐、血钾、血压水平变化,计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果研究组的HR为(67.72±9.88)次/min,LVMI为(122.43±19.88)g/m2,参照组的HR为(73.18±10.54)次/min,LVMI为(134.98±21.34)g/m2,研究组HR、LVMI与参照组比较差异均有统计学意义(均P<0.05)。研究组的收缩压治疗前为(158.34±14.88)mm Hg(1 mm Hg=0.133 k Pa),治疗后为(122.09±10.32)mm Hg,舒张压治疗前为(98.47±10.50)mm Hg,治疗后为(79.16±6.45)mm Hg,参照组的收缩压治疗前为(157.41±14.25)mm Hg,治疗后为(125.13±12.33)mm Hg,舒张压治疗前为(98.23±10.12)mm Hg,治疗后(80.49±6.82)mm Hg,治疗前后对比差异均有统计学意义(均P<0.05)。结论咪达普利和缬沙坦联合治疗能逆转原发性高血压患者的左心室肥厚,值得推广应用。
Objective To investigate the reversal of left ventricular hypertrophy in patients with essential hypertension by combination of imidapril and valsartan. Methods Totally 77 patients with essential hypertension admitted to our hospital from February 2014 to February 2015 in our hospital were enrolled in this study. Patients were randomly assigned to receive treatment with Imidapril (reference group, A total of 38 cases), while the other group used the combined treatment of Imidapril and valsartan (study group, a total of 39 cases). The reference group took imidapril 10 mg / d, adjusted according to the patient’s condition. The study group was treated with 10 mg / day of imidapril and 80 mg / day of valsartan, adjusted for changes in the patient’s condition. The changes of LVMI, heart rate, creatinine, serum potassium and blood pressure were observed. The measurement data were analyzed by t test. The count data were analyzed byχ2 test. The difference was statistically significant at P <0.05. Results The HR of the study group was (67.72 ± 9.88) / min, the LVMI was (122.43 ± 19.88) g / m2, the HR of the reference group was (73.18 ± 10.54) / min and the LVMI was (134.98 ± 21.34) g / m2 , There was significant difference between study group HR, LVMI and reference group (all P <0.05). The systolic blood pressure in the study group was (158.34 ± 14.88) mm Hg before treatment (122.09 ± 10.32) mm Hg after treatment and (98.47 ± 10.50) mm Hg before treatment (79.16 ± 6.45) mm Hg after treatment and (157.41 ± 14.25) mm Hg before treatment in the reference group, (125.13 ± 12.33) mm Hg after treatment and (98.23 ± 10.12) mm Hg before treatment, respectively After treatment (80.49 ± 6.82) mm Hg, there were significant differences between before and after treatment (all P <0.05). ConclusionImidapril and valsartan combined therapy can reverse left ventricular hypertrophy in patients with essential hypertension, it is worth promoting the application.