本文对职业性接触者的染色体异常、实验研究和染色体异常的机理进行了展望,同时对于工业医学和细胞遗传学的关系进行了讨论。 职业性因素所致的染色体异常 1.苯 Vigliani等在1964年报道,使用苯的工人白血病的发病率比一般人高20倍以上。Tough等人认为,接触1～20年苯的20名工人与对照组比其染色体断裂数明显增加。 另外,Pollini等报告,对长期接触苯具 This article looks at the chromosomal abnormalities, experimental studies and chromosomal abnormalities in occupational contacts, and discusses the relationship between industrial medicine and cytogenetics. Chromosomal Abnormalities Caused by Occupational Factors 1. Benzene Vigliani et al reported in 1964 that the incidence of leukemia in workers using benzene was more than 20 times higher than in the general population. According to Tough et al., 20 workers exposed to benzene for 1 to 20 years had a significantly higher number of chromosome breaks than controls. In addition, Pollini et al. Reported long-term exposure to benzene