论文部分内容阅读
目的:观察中药复方复宫止血胶囊对药流大鼠子宫内膜病理变化和蜕膜组织Fas、FasL的影响,探讨其减少药物流产后出血的机理。方法:将妊娠大鼠24只造模后随机分为3组,模型组、益母草组、复宫止血胶囊组,妊娠第13天是处死各组大鼠,光镜观察大鼠子宫内膜病理变化,免疫组化法检测各组大鼠蜕膜组织Fas、FasL表达。结果:复宫止血胶囊各组Fas平均OD值显著高于模型组和益母草组(P<0.05),复宫止血胶囊各组FasL平均OD值显著高于模型组和益母草组(P<0.05)。结论:复宫止血胶囊能够促进蜕膜组织Fas、FasL表达,促进蜕膜组织凋亡。
OBJECTIVE: To observe the effect of Fugongzhixue capsule on the pathological changes of endometrial and decidua Fas and FasL in drug-fed rats, and to explore the mechanism of reducing bleeding after medical abortion. METHODS: Twenty-four pregnant rats were randomly divided into 3 groups: model group, motherwort group, Fugongzhixue capsule group. Rats in each group were sacrificed on the 13th day of pregnancy. The pathological changes of the endometrium in rats were observed by light microscopy. The expression of Fas and FasL in the decidua of rats in each group was detected by immunohistochemistry. Results: The average OD value of Fas in Fugong Zhixue Capsule was significantly higher than that in model group and Leonurus group (P<0.05). The average OD value of FusL in Fugong Zhixue capsule was significantly higher than that in model group and Leonurus group (P<0.05). Conclusion: Fugongzhixue Capsule can promote the expression of Fas and FasL in decidua and promote the apoptosis of decidua.