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一般外科手术之后均有一段时间发生广泛的免疫抑制,这可能有利于恶性肿瘤病人手术过程中种植转移。作者研究了围手术期低剂量α-干扰素对于防止宿主手术后抗肿瘤免疫机制抑制的作用。研究对象是术前已证实为胃或结肠直肠肿瘤并拟定切除的患者,随机分为两组,各15例。对照组常规手术治疗;治疗组于手术前一天开始接受为期7天的α-干扰素2a治疗,2大单位/日,皮下给药,给药时间均在18:00时。所有患者都能耐受该项治疗,无一例发生常出现于接受大剂量干扰素治疗者的肌痛症、α-干扰素治疗组平均体温轻度升高,可能反映了术后肺、尿路、和伤口感染略有增加。作者测定了术前1日和术后1、3、5、10日的自然杀伤细胞活性、淋巴因子激活的杀伤细胞细胞毒性和内源性白细胞介素—2产物。白细胞介素—2两组均于手术后1日明显下降,两组间无明显差异;但第三天对照组已稍回升时,α-干
Extensive immunosuppression occurs for a period of time after general surgery, which may be beneficial for the implantation of malignant tumor patients during surgery. The authors studied the role of low-dose interferon alpha in the perioperative period in preventing the suppression of anti-tumor immune mechanisms after host surgery. The subjects were those who had been confirmed as having stomach or colorectal neoplasms before surgery and were scheduled for resection. They were randomly divided into two groups, each with 15 cases. The control group received routine surgical treatment; the treatment group began to receive a 7-day treatment with α-interferon 2a on the day before surgery, with 2 large units/day, subcutaneous administration, and administration at 18:00. All patients were able to tolerate the treatment. No case of myalgia often present in patients receiving large doses of interferon and mild increase in mean body temperature in the alpha-interferon treatment group may reflect the postoperative lung and urinary tract. There is a slight increase in wound infection. The authors measured the natural killer cell activity, lymphokine-activated killer cell cytotoxicity, and endogenous interleukin-2 production on the day before surgery and 1, 3, 5, and 10 days after surgery. Interleukin-2 was significantly decreased on the 1st day after surgery and there was no significant difference between the two groups. However, on the third day, the control group had slightly increased, α-D