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目的观察替米沙坦联合百灵胶囊对早期2型糖尿病肾病(T2DN)患者尿微量白蛋白的影响。方法 86例未服用ACEI类和ARB族药物的T2DN患者,随机分为对照组(替米沙坦组)42例,口服替米沙坦80mg/d;联合治疗组44例,口服替米沙坦80mg/d+百灵胶囊90g/d,20w后联合治疗组与对照组比较治疗前后24h尿微量白蛋白排泄率(UAE)、血钾、血肌酐水平。结果联合用药组降低UAE效果显著优于对照组(P<005)。结论替米沙坦联合百灵胶囊对延缓早期2型糖尿病肾病(T2DN)进展起协同作用。
Objective To observe the effect of telmisartan combined with Bailing capsule on urinary albumin in patients with early type 2 diabetic nephropathy (T2DN). Methods A total of 86 patients with T2DM who did not take ACEI and ARB drugs were randomly divided into control group (telmisartan group) and oral telmisartan 80 mg / d (n = 44). Telmisartan The levels of urinary albumin excretion (UAE), serum potassium and serum creatinine in the combined treatment group and the control group were compared before and after treatment with 80mg / d + Bailing capsule 90g / d for 20 weeks. Results The effect of reducing UAE in combination group was significantly better than that in control group (P <005). Conclusion Telmisartan combined with Braun capsule can delay the progression of early type 2 diabetic nephropathy (T2DN).