论文部分内容阅读
目的了解保山市葡萄糖-6-磷酸脱氢酶(G6PD)缺乏情况,为疾病防治和临床诊疗提供参考。方法采用纯化学反应荧光法对8 712例标本进行G6PD缺乏症的筛查。结果 8 712例标本中共筛查出阳性98例,阳性率为1.12%。G6PD筛查阳性率最高为腾冲县2.00%,隆阳区最低为0.43%,各县区差异有统计学意义(χ2=37.34,P<0.01)。男性G6PD缺乏筛查检出率为1.54%,女性为0.43%,差异有统计学意义(χ2=22.40,P<0.01)。回族G6PD筛查检出率最高为3.81%,其次是彝族1.71%,傣族1.63%,最低为布朗族0.70%,不同民族检出率差异有统计学意义(χ2=12.21,P<0.01)。结论保山市人群G6PD缺乏筛查阳性率为1.12%,在病例治疗过程中应做好相应筛查,以防抗疟药及其它药物引起溶血反应。
Objective To understand the shortage of glucose-6-phosphate dehydrogenase (G6PD) in Baoshan and provide reference for disease prevention and treatment. Methods A total of 8 712 samples were screened for G6PD deficiency using pure chemical reaction fluorescence. Results A total of 987 positive samples were found in 8 712 samples, the positive rate was 1.12%. The highest positive rate of G6PD screening was 2.00% in Tengchong County and 0.43% in Longyang County. There was significant difference among counties (χ2 = 37.34, P <0.01). The detection rate of G6PD deficiency in males was 1.54% and in females was 0.43%, the difference was statistically significant (χ2 = 22.40, P <0.01). The detection rate of G6PD in Hui population was the highest (3.81%), followed by Yi people (1.71%) and Dai people (1.63%), while the lowest was Brown people (0.70%). The detection rate of different ethnic groups was statistically different (χ2 = 12.21, P <0.01). Conclusion The positive rate of G6PD deficiency screening in Baoshan is 1.12%. Corresponding screening should be done in the course of treatment to prevent the anti-malarial drugs and other drugs from causing hemolytic reaction.