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神经肽y(neuropeptide-Y,NPY)广泛存在于中枢神经系统,尤其下丘脑含量非常丰富,是一种重要的神经内分泌调质,参与多种生理功能的调节,多数学者认为NPY既是神经递质又是内分泌调节物质,在中枢系统可以调节下丘脑-垂体各靶腺轴激素的合成和释放。目前,实验已证实下丘脑和垂体内存在着大量的神经肽y样神经纤维,在垂体细胞中也存在神经肽y分泌颗粒及其mRNA表达,表明在下丘脑和垂体内神经肽y与激素分泌密切相关,并且与垂体腺瘤的发生、发展有某些必然的联系。
Neuropeptide-Y (NPY) is widely distributed in the central nervous system, especially the hypothalamus is very rich in content, is an important neuroendocrine regulation, involved in the regulation of many physiological functions, most scholars believe that NPY is both neurotransmitter It is also an endocrine regulatory substance that regulates the synthesis and release of hormones in the hypothalamus-pituitary gland in the central nervous system. At present, the experiment has confirmed that there are a large number of neuropeptide y-like nerve fibers in the hypothalamus and pituitary, neuropeptide Y secretion particles and their mRNA expression in pituitary cells, indicating that in the hypothalamus and pituitary neuropeptide y and hormone secretion close Related, and with the occurrence and development of pituitary adenomas have some necessary connection.