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概述:血液中嗜酸性粒细胞浓度增加可能会导致心内膜炎、心肌炎乃至心包炎。当嗜酸性粒细胞计数超过1.5×10~9/L时,心肌会受损,甚至会发生死亡。本文报告的病例关于一位患酒精所致精神障碍的47岁男性,经喹硫平50mg/d~200 mg/d的剂量治疗4周后发生嗜酸性粒细胞增多症。患者的嗜酸性粒细胞高达7.63x10~9/L(正常范围<0.5×10~9/L),但停用喹硫平4周后恢复正常,没有心肌受损的表现。该患者突发嗜酸性粒细胞增多症,并无任何相关的临床症状,只是在服用喹硫平数周后常规血液学检查时才发现的。这提醒所有医生在使用抗精神病药物治疗患者时要警惕这种罕见但会危及生命的不良反应。
Summary: Increased concentrations of eosinophils in the blood can cause endocarditis, myocarditis and pericarditis. When eosinophils count more than 1.5 × 10 ~ 9 / L, myocardial damage, and even death. This article reports a 47-year-old man with an alcohol-induced psychotic disorder who developed eosinophilia 4 weeks after a dose of quetiapine 50 mg / day to 200 mg / day. Patients with eosinophils up to 7.63x10 ~ 9 / L (normal range <0.5 × 10 ~ 9 / L), but withdrawal of quetiapine returned to normal after 4 weeks, there is no myocardial damage. The patient had sudden eosinophilia without any relevant clinical symptoms, only found on routine hematological examination after a few weeks of quetiapine treatment. This reminds all doctors to be alert to this rare but life-threatening adverse reaction when using antipsychotics.