文献提出系统性化疗对肝细胞癌(HCC)疗效很差,一次性肝动脉大剂量注射化疗药物亦无成效,继而来用肝动脉栓塞化疗的方法,但仍有一定的局限性。 本实验采用去甲斑蠡素、藤黄酸肝内局部注射,示踪测定局部药物浓度的变化,并与环磷酰胺,无水乙醇等对照观察肝脏局部的组织效应。现将结果报告如下。 The literature suggests that systemic chemotherapy has poor therapeutic effects on hepatocellular carcinoma (HCC), and that large-dose hepatic arterial injections of chemotherapeutic agents are also ineffective, followed by methods of hepatic artery embolization chemotherapy, but there are still some limitations. In this experiment, the local intrahepatic injections of norcantharidin and gambogic acid were used to trace the changes of local drug concentration, and the liver tissue effects were observed with cyclophosphamide and anhydrous ethanol. The results reported below.