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目的探讨X线修复交叉互补基因1(XRCC1)399位点多态性与肝细胞癌发病风险之间的关系。方法检索国内外数据库,获得有关XRCC1基因多态性与肝细胞癌发病风险的病例-对照研究资料,用Review Manager 4.2.8分析软件对纳入本项Meta分析的各研究数据进行综合统计处理及异质性检验,计算合并的OR值(95%CI)。结果符合纳入标准的共有7篇文献。累计肝细胞癌病例1133例,对照1747例。Meta分析结果显示,与野生基因型Arg/Arg相比,杂合变异基因型Arg/Gln和(Arg/Gln+Gln/Gln)合并的OR值(95%CI)均为1.00(0.68,1.47),纯合变异基因型Gln/Gln合并的OR值(95%CI)为1.02(0.60,1.72)。XRCC1 399位点多态性与肝细胞癌的发病风险之间的关系均无统计学意义。结论未发现XRCC1 399位点多态性与肝细胞癌发病风险之间的统计学相关性。
Objective To investigate the relationship between polymorphism of XRCC1 399 locus and the risk of hepatocellular carcinoma. Methods The databases of domestic and foreign patients were searched to obtain the case-control study data about the polymorphism of XRCC1 gene and the risk of hepatocellular carcinoma. The data of each study included in this meta-analysis were comprehensively analyzed by Review Manager 4.2.8 software Qualitative tests were performed to calculate the combined odds ratio (95% CI). The results meet the inclusion criteria of a total of seven articles. A total of 1133 cases of hepatocellular carcinoma, control of 1747 cases. Meta analysis showed that the OR (95% CI) of the combination of Arg / Gln and (Arg / Gln + Gln / Gln) were all 1.00 (0.68, 1.47) compared with wild type Arg / Arg , OR (95% CI) of the homozygous genotype Gln / Gln combined was 1.02 (0.60, 1.72). No relationship was found between XRCC1 399 polymorphism and the risk of developing HCC. Conclusion No statistical relationship between polymorphism of XRCC1 399 locus and the risk of hepatocellular carcinoma was found.