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目的:评价4-甲基环十五烷酮对血管性痴呆大鼠学习记忆力的影响。方法:采用大鼠90只,按体重随机分为金纳多注射液(6.1 mg.kg-1)阳性对照组,模型对照组,以及假手术对照组,4-甲基环十五烷酮高、中、低剂量组(8.1,2.7,0.9mg.kg-1)。以结扎双侧颈动脉法造模,各组从造模后7 d开始灌胃给药,每天1次,连续给药28 d,给药体积均为10 mL.kg-1。模型对照组和假手术对照组给予等容量的生理盐水,观察各组实验动物的行为学和脑组织匀浆相关的生化指标。结果:4-甲基环十五烷酮以8.1,2.7 mg.kg-1灌胃时,避暗计数及脑组织匀浆总胆碱酯酶(TChE)活性较模型组明显降低(P<0.05);4-甲基环十五烷酮在8.1 mg.kg-1时,脑组织匀浆超氧化物歧化酶(SOD)活性较模型组明显升高(P<0.05)。结论:4-甲基环十五烷酮对改善血管性痴呆大鼠学习记忆力有一定的作用。
Objective: To evaluate the effect of 4-methylcyclopentadecanone on learning and memory in vascular dementia rats. Methods: Ninety rats were randomly divided into seven groups according to body weight: positive control group, model control group, sham operation control group, 4-methylcyclopentadecan-1-one , Medium and low dose groups (8.1, 2.7, 0.9 mg.kg-1). Bilateral carotid arteries were ligated. The rats in each group were administered intragastrically 7 days after the model was established. The rats in each group were administered once a day for 28 consecutive days with a volume of 10 mL.kg-1. The model control group and the sham operation control group were given the same volume of saline, and the behavioral and histochemical biochemical indexes of the experimental animals were observed. Results: Compared with model group, 4-methylcyclopentadecan-1-one was administered at 8.1 and 2.7 mg.kg-1 respectively, the dark-avoidance count and TChE activity in brain homogenate were significantly lower than those in model group (P <0.05 ). The activity of superoxide dismutase (SOD) in brain homogenate of 4-methylcyclopentadecanone at 8.1 mg.kg-1 was significantly higher than that of model group (P <0.05). Conclusion: 4-methylcyclopentadecan-1 has a certain effect on learning and memory in vascular dementia rats.