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目的:为临床安全使用卡铂提供药学信息和药学服务。方法:报告卡铂化疗中出现的3例不良反应,包括2例胸闷憋气、血压下降和1例严重的过敏性休克。结合案例对卡铂过敏的报道进行文献检索分析。结果:根据病例及文献汇总,分析卡铂过敏反应的发生特点、机制、危险因素、预防方式以及后续治疗方法,总结卡铂过敏反应的相关药学信息和药学服务要点。结论:药师通过临床治疗实践,获得积累卡铂过敏反应的相关知识和经验并为临床治疗选择提供药学服务。
Purpose: To provide pharmacy information and pharmacy services for the safe use of carboplatin for clinical purposes. METHODS: Three adverse reactions were reported in carboplatin chemotherapy, including two cases of chest tightness and suffocation, a decrease in blood pressure and one case of severe anaphylactic shock. Combined with case reports of carboplatin allergy literature search analysis. Results: According to the case and literature summary, we analyzed the characteristics, mechanism, risk factors, prevention methods and follow-up treatment of carboplatin allergy, and summarized the related pharmacy information and pharmacy service points of carboplatin allergy. Conclusion: Through clinical practice, pharmacists gain knowledge and experience of accumulating carboplatin allergy and provide pharmacological services for clinical treatment.