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目的 :探讨动脉硬化性闭塞症 (arteriosclertosisobliteransASO)的发病机理和原儿茶醛 (protocatechuicaldehyde ,PCA)的抗炎、抗动脉粥样硬化作用机理。 方法 :趋化游走实验法、ELISA法和间接免疫荧光法等。 结果 :(1)ASO组白细胞趋化游走的数目大于献血员组 ;(2 )PCA处理的两组的趋化游走的白细胞数目少于各自的对照组 ;(3)ASO对照组的外周血单个核细胞(peripheralbloodmononuclearcellsPBMNC)产生的IL 8活性高于献血员对照组 ;(4 )PCA处理的献血员组和PCA处理的血瘀型组的PBMNC产生的IL 8活性低于各自的对照组。 结论 :血瘀型组白细胞趋化游走能力增强 ;其PBMNC产生的IL 8活性增高 ;PCA抑制白细胞趋化游走和PBMNC产生的IL 8活性增高。这些抑制作用是PCA改善微循环、抗炎和抗动脉粥样硬化作用机制的一部分。
Objective: To investigate the pathogenesis of arteriosclerosis obliterans ASO and the anti-inflammatory and anti-atherosclerotic mechanism of protocatechuicaldehyde (PCA). Methods: chemotactic migration assay, ELISA and indirect immunofluorescence. Results: (1) The numbers of leukocyte chemotaxis in ASO group were larger than those in blood donors; (2) The number of chemotactic walking leukocytes in PCA-treated groups was less than that of the control group; (3) IL-8 activity of peripheral blood mononuclear cells PBMNCs was higher than that of donor control group; (4) PBMNCs of PCA-treated blood donors group and PCA-treated blood stasis group produced lower IL 8 activity than their respective control groups. Conclusion: The leukocyte chemotaxis in blood stasis type group is enhanced; the activity of IL 8 produced by PBMNC is increased; PCA inhibits leukocyte chemotaxis and IL 8 activity in PBMNC. These inhibitory effects are part of the mechanism by which PCA improves microcirculation, anti-inflammatory and anti-atherosclerotic effects.