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目的:观察中西医结合治疗严重胸部创伤致急性肺损伤(ALI)的临床疗效。方法:选取2012年12月至2015年12月丰都县人民医院收治的因严重胸部创伤所致的ALI患者共50例,随机分为对照组和观察组,各25例;对照组患者予以西医常规治疗,观察组在此基础上予以大承气汤加减进行治疗;记录两组患者的机械通气时间和住院时间,并对血清超氧化物歧化酶(SOD)活性、肿瘤坏死因子-α(TNF-α)含量和氧合指数、动脉血氧分压的变化情况进行对比。结果:观察组患者机械通气时间和住院时间缩短,治疗后血清SOD活性升高、TNF-α含量下降,动脉血氧分压及氧合指数升高,与对照组比较,差异具有统计学意义(P<0.05)。结论:中西医结合治疗严重胸部创伤致ALI的疗效确切。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of acute lung injury (ALI) caused by severe chest trauma. Methods: A total of 50 patients with ALI due to severe thoracic trauma admitted to Fengdu County People’s Hospital from December 2012 to December 2015 were randomly divided into control group and observation group, with 25 cases each. Patients in the control group were treated with Western medicine The patients in the observation group were treated with Dachengqi Decoction. The mechanical ventilation time and hospital stay of the two groups were recorded. The activities of superoxide dismutase (SOD), tumor necrosis factor-α -α) content and oxygenation index, arterial oxygen partial pressure changes were compared. Results: The duration of mechanical ventilation and hospital stay in observation group were shortened. After treatment, serum SOD activity, TNF-α level decreased, arterial partial pressure of oxygen and oxygenation index increased, compared with the control group, the difference was statistically significant ( P <0.05). Conclusion: Integrative treatment of severe thoracic injury caused by ALI exact effect.