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胃泌素、乙酰胆碱和组胺参与胃壁细胞的盐酸分泌。但其分泌过程不断受所谓质子泵(H~+/K~+-ATP酶)的控制,质子通过质子泵消耗ATP,与钾离子交换而到达胃腔。奥美拉唑(omeprazol)在转化成有活性的次硫酰胺之前,在胃壁细胞上质子化。每两个次硫酰胺分子与H~+/K~+-ATP酶发生反应,从而抑制这种酶的活性。停用奥美拉唑后7～10天,胃酸的分泌又恢复正常。奥美拉唑由小肠吸收,经肾排出。其特异性高,至今未见其对其它组织的不良作用。出于奥美拉唑使胃酸减少,存在细菌在
Gastrin, acetylcholine and histamine are involved in the secretion of hydrochloric acid from gastric parietal cells. However, its secretion process is constantly controlled by the so-called proton pump (H ~ + / K ~ + -ATPase). Protons consume ATP through the proton pump and exchange with potassium ions to reach the gastric cavity. Omeprazol is protonated on gastric parietal cells prior to conversion to the active sulfoxide. Each two sulfoxide molecules and H ~ + / K ~ + -ATP enzyme reaction, thus inhibiting the activity of this enzyme. After stopping omeprazole 7 to 10 days, gastric acid secretion returned to normal. Omeprazole absorbed by the small intestine, the kidneys discharged. Its high specificity, so far no adverse effects on other tissues. Out of omeprazole to reduce gastric acid, the presence of bacteria in the