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目的探讨羊膜腔输注抗生素预防胎膜早破感染的效果。方法将６７例胎膜早破的产妇，随机分为两组。实验组（３４例）经宫颈羊膜腔输注青霉素８０万Ｕ，对照组（３３例）静脉注射青霉素６４０万Ｕ。通过对两组产前宫颈分泌物、羊水、新生儿咽拭子细菌培养以及胎膜病理检查结果的对照观察，进行卡方检验。结果差异有显著性意义（Ｐ＜０．０１）。结论羊膜腔输注青霉素对杀灭羊水中的细菌、控制绒毛膜羊膜炎的发展效果显著，值得在临床推广使用。
Objective To investigate the effect of amniotic infusion of antibiotics in preventing premature rupture of membranes. Methods 67 cases of premature rupture of membranes were randomly divided into two groups. In the experimental group (34 cases), penicillin 800000 U was injected into the amniotic cavity of the cervix, while the control group (33 cases) received penicillin 6.4 million U. Through the two groups of prenatal cervical secretions, amniotic fluid, neonatal throat swab bacterial culture and fetal control examination of the results of pathological examination, chi-square test. The difference was significant (P <0.01). Conclusion Amniotic penicillin infusion is effective in killing amniotic fluid bacteria and controlling chorioamnionitis, which is worthy of clinical application.