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胃癌的发生、发展是由癌基因的激活、抑癌基因的失活或端粒酶的激活等引发的多因素、多阶段、多基因的综合病变过程,其中近年来的研究热点之一是抑癌基因的异常甲基化。抑癌基因的异常甲基化是可遗传与可逆转的DNA改变,目前研究发现逆转抑癌基因异常甲基化可恢复或可增强其蛋白表达,恢复已失活的抑癌基因的抗肿瘤作用。随着有关抑癌基因去甲基化研究的逐渐深入,去甲基化干预有望成为胃癌治疗的新途径。
The occurrence and development of gastric cancer is caused by the activation of oncogenes, the inactivation of tumor suppressor genes or the activation of telomerase and other multi-factor, multi-stage, multi-gene integrated disease process, in which one of the hot spots in recent years is inhibition Aberrant methylation of oncogenes. Aberrant methylation of tumor suppressor genes is a heritable and reversible DNA change. Up to now, it has been found that reversing the abnormal methylation of tumor suppressor gene can restore or enhance its protein expression and restore the anti-tumor effect of the inactivated tumor suppressor gene . With the demethylation of tumor suppressor gene in-depth study, demethylation intervention is expected to become a new approach to the treatment of gastric cancer.