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全球范围内性传播感染（STIs）的发病正在逐年上升，治疗面临重大挑战。优化现有抗菌药物的剂量和给药方案，或采用联合治疗是改善治疗结局的重要策略，但不同药物的特性和不良反应以及感染部位均对治疗结果有直接影响。本文将从以上方面对当前用于STIs治疗的主要抗菌药物进行阐述。“,”The incidence of sexually transmitted infections(STIs) is rising worldwide, and the treatment is faced with significant challenges. Optimizing the drug dosage and regimens or using combination therapy is an important strategy to improve the prognosis. However, the peculiarities of different drugs, infection site and adverse drug reactions directly affect the treatment outcomes. The above aspects of main antibiotics currently used for the treatment of STIs are review in this article.