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目的探讨阴道用乳杆菌活菌胶囊(定君生)联合复方黄柏液外用对促进子宫全切术后阴道残端愈合的临床疗效。方法选取2014年因妇科良性、非炎症性疾病在四川省人民医院妇科实施子宫全切术的患者160例,分为研究组和对照组,每组各80例。研究组于术后10 d开始予以复方黄柏液稀释坐盆,1次/d,坐盆完毕后予乳杆菌活菌胶囊阴道内放置,1粒/d,连续10 d;对照组无用药。比较两组阴道残端愈合率、阴道残端出血率、阴道残端肉芽组织形成率、阴道清洁度异常率、阴道菌群失调检出率、细菌性阴道病的检出率。结果研究组甲级愈合率为88.75%,高于对照组的72.5%(P<0.05),研究组阴道残端出血率(1.25%)、阴道残端肉芽形成率(2.5%)、阴道清洁度异常率(27.5%)、阴道菌群失常检出率(18.75%)、细菌性阴道病的检出率(1.25%)均低于对照组(8.75%、11.25%、60.0%、33.75%、8.75%)(P<0.05)。结论阴道用乳杆菌活菌胶囊联合复方黄柏液用于子宫全切除术后可减轻阴道残端的炎症反应,调节阴道菌群,改善阴道环境,减少阴道炎症发生,促进阴道残端愈合。
Objective To investigate the clinical efficacy of vaginal Lactobacillus live capsule (Ding Junsheng) combined with Cortex Phellodendri liquid on promoting the healing of vaginal stump after total hysterectomy. Methods A total of 160 patients with gynecologic benign and non-inflammatory gynecological gynecological hysterectomy in Sichuan Provincial People’s Hospital were enrolled in this study. The patients were divided into study group and control group with 80 cases in each group. The study group was given compound cortex phellodeis from the 10th day after the operation, and once a day, the lactobacilli viable capsule was placed intravaginally in the vagina for 1 day for 10 consecutive days. The control group was given no drug. The healing rate of vaginal stump, vaginal stump bleeding rate, vaginal stump granulation tissue formation rate, vaginal cleanliness abnormality rate, vaginal flora detection rate, bacterial vaginosis detection rate were compared between the two groups. Results The grade A healing rate was 88.75% in the study group, which was significantly higher than that in the control group (72.5%, P <0.05). In the study group, the bleeding rate of gastric stump (1.25%), granulation rate of vaginal stump (2.5%), vaginal cleanliness The abnormal rate (27.5%), the prevalence of vaginal flora (18.75%) and bacterial vaginosis (1.25%) were lower than those in the control group (8.75%, 11.25%, 60.0%, 33.75%, 8.75 %) (P <0.05). Conclusions Vaginal Lactobacillus live capsule combined with Cortex Phellodendri fluid can relieve vaginal stump inflammatory reaction, regulate vaginal flora, improve vaginal environment, reduce vaginal inflammation and promote the healing of vaginal stump.