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目的：观察和分析运动（ＥＸ）、巯甲丙脯酸（ＣＡＰ）及巯甲丙脯酸运动（ＣＡＰ－ＥＸ）介入对轻中度原发性高血压（ＥＨ）患者肾功能的影响。方法：１０例正常志愿者和１５例轻中度原发性高血压患者，在１个月内完成基础双核素肾显像（ＢＳ－ＲＳ）、运动双核素肾显像（ＥＸ－ＲＳ）、巯甲丙脯酸双核素肾显像（ＣＡＰ－ＲＳ）及巯甲丙脯酸运动双核素肾显像（ＣＡＰ－ＥＸ－ＲＳ）４次检查。图像均按ＡＤＡＣ公司提供的计算机软件进行处理。结果：ＥＸ和ＣＡＰ－ＥＸ介入，ＧＦＲ，ＥＲＰＦ均明显降低（Ｐ＜００１）；而ＣＡＰ介入未见明显变化。ＥＨ组与对照组相应方法间ＧＦＲ，ＥＲＰＦ不存在显著差异（Ｐ＞００５）。１５例ＥＨ患者中，基础肾显像及巯甲丙脯酸肾显像结果均正常，而４０％（６／１５）的患者出现异常运动肾图，３０％（５／１５）出现异常巯甲丙脯酸运动肾图，二者同时异常的有５例，其中１例于ＣＡＰ－ＥＸ－ＲＳ介入时，异常更加明显，均表现为对称性的１３１Ｉ－ＯＩＨ和９９ｍＴｃ－ＤＴＰＡ排泄延迟，１３１Ｉ－ＯＩＨ肾图和９９ｍＴｃ－ＤＴＰＡ肾图曲线宽大，排泄段抬高。上述异常变化在１３１Ｉ－ＯＩＨ和９９ｍＴｃ－ＤＴＰＡ肾图曲线中，以９９ｍＴｃ－ＤＴＰＡ肾图?
OBJECTIVE: To observe and analyze the effects of exercise, captopril and CAP-EX intervention on renal function in patients with mild to moderate essential hypertension (EH). Methods: Ten patients with normal volunteers and 15 patients with mild to moderate essential hypertension were enrolled in this study. Basic BSS, EX-RS, CAP-RS and CAP-EX-RS of captopril were performed 4 times. Images are processed by computer software supplied by ADAC. Results: The intervention of EX and CAP-EX, GFR and ERPF were significantly decreased (P <001), while there was no obvious change in CAP intervention. There was no significant difference in GFR and ERPF between EH group and control group (P> 005). Of the 15 EH patients, the results of basic renal imaging and captopril renal imaging were normal, while abnormal motor map was observed in 40% (6/15) of patients and abnormal thromboxane in 30% (5/15) There were 5 cases with abnormal both of them at the same time. Among them, 1 case was involved in the CAP-EX-RS intervention, the abnormality was more obvious. All showed symmetrical 131I-OIH and 99mTc-DTPA excretion delay, 131I- OIH renogram and 99mTc-DTPA renal figure wide curve, excretion elevation. The abnormal changes in the 131I-OIH and 99mTc-DTPA renogram curve to 99mTc-DTPA renal diagram?