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目的 :观察合成同化甾体激素 19 去甲睾酮 (NT)对性腺发育不良 (hpg)小鼠的前列腺、精囊腺 (SV)、附睾生长发育的影响 ,为用药的安全性提供实验依据。 方法 :NT硅胶囊皮下埋植 5周缓释给药 ,设给药hpg小鼠实验组 (n =7)、不给药hpg小鼠对照组 (n =7)和性腺发育正常小鼠对照组 (n =10 )。给药结束后测定前列腺腹侧叶(VP)、SV和附睾的重量及VP腺管末梢数目。 结果 :与hpg小鼠对照组相比 ,hpg小鼠给药组各附性腺的重量均显著增加 (P <0 .0 0 5 ) ,VP腺管分支形态发育趋于正常 ;hpg小鼠给药组SV的重量与正常小鼠相同 ,但VP、附睾的重量及VP腺管末梢数目仍显著低于正常性腺小鼠对照组 (P <0 .0 0 5 )。 结论 :NT能明显刺激hpg小鼠附性腺的生长发育
OBJECTIVE: To observe the effects of synthetic anabolic steroid hormone 19 (NT) on the growth of prostate, seminal vesicle (SV) and epididymis in hypogonadal mice (hpg) mice and provide experimental evidence for its safety. Methods: NT silicone capsule was implanted subcutaneously for 5 weeks. The experimental group (n = 7), the control group (n = 7) and the control group of normal gonadal development mice (n = 10). After the administration, the weights of the ventral lobes (VP), SV and epididymis and the number of VP glenoid terminals were measured. Results: Compared with the hpg mouse control group, the weight of each accessory gland in the hpg mice administration group was significantly increased (P <0.05), and the morphological development of VP gland branches tended to be normal. The hpg mice The weight of group SV was the same as that of normal mice, but the weight of VP, epididymis and the number of VP gland terminals were still significantly lower than those of normal gonadal mice (P <0.05). Conclusion: NT can obviously stimulate gpg mouse gonadal growth and development