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目的探讨姜黄素对脑缺血模型大鼠SOD酶活性及Akt磷酸化水平的影响。方法48只SD大鼠随机均分为假手术组、手术模型组、姜黄素低、高剂量组。采用Zea Longa线栓法制作模型,检测各组大鼠的SOD活性和Akt磷酸化水平。结果与假手术组比,模型组和姜黄素低、高剂量组SOD活性下降;与模型组比较,姜黄素低、高剂量组SOD活性升高(P<0.05),但姜黄素低、高剂量组的SOD活性差异无显著性(P>0.05);与假手术组比较,模型组的Akt磷酸化水平显著下降(P<0.01),姜黄素低、高剂量组Akt磷酸化较模型组显著升高(P<0.01),且高剂量组的Akt磷酸化水平较低剂量组高(P<0.01)。结论姜黄素对脑缺血的保护作用可能与提高SOD活性及Akt磷酸化水平有关。
Objective To investigate the effect of curcumin on SOD activity and Akt phosphorylation in cerebral ischemia model rats. Methods 48 SD rats were randomly divided into sham operation group, operation model group, curcumin low and high dose group. The model of Zea Longa suture method was used to detect the SOD activity and Akt phosphorylation in each group. Results Compared with sham operation group, the activity of SOD in model group and curcumin low and high dose group decreased. Compared with model group, the activity of SOD in curcumin low and high dose group increased (P <0.05), but curcumin low and high dose (P> 0.05). Compared with the sham-operation group, Akt phosphorylation in model group decreased significantly (P <0.01), Akt phosphorylation in curcumin low and high dose group was significantly higher than that in model group (P <0.01), and Akt phosphorylation in high dose group was higher than that in lower dose group (P <0.01). Conclusion The protective effect of curcumin on cerebral ischemia may be related to increasing SOD activity and Akt phosphorylation.