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近年来,真菌感染的发病率和病死率呈明显上升趋势,尤其对癌症放疗、化疗患者、器官移植患者以及介入治疗患者更是致命的威胁。究其原因,一方面缘于广谱抗生素、肾上腺皮质激素、抗肿瘤药、免疫抑制剂的滥用,导致菌群失调和机体对真菌的抵抗力降低,致使真菌感染易于发生并难以控制;另一方面,由于真菌与人类细胞同为真核细胞,长期用药后往往对宿主具有相当的毒性,并且随着抗真菌药物的运用,真菌的
In recent years, the incidence of fungal infections and mortality showed a clear upward trend, especially for cancer radiotherapy, chemotherapy patients, organ transplant patients and interventional patients is even more deadly threat. The reason, on the one hand due to broad-spectrum antibiotics, adrenal hormones, anti-tumor drugs, the abuse of immunosuppressive agents, leading to flora and reduce the body's resistance to fungi, resulting in fungal infections prone and difficult to control; the other As the fungi and human cells are eukaryotic cells, they often have considerable toxicity to the host after long-term administration, and with the use of antifungal drugs, the fungal