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本工作观察了预先给予消炎痛对四氧嘧啶引起的糖尿病大鼠血糖、血清胰岛素和胰高血糖素浓度的影响。结果表明:预先皮下注射消炎痛能使糖尿病大鼠血糖浓度明显降低,并且具有明显的量效关系。在消炎痛剂量5,10,15mg/kg时,注射四氧嘧啶48h后血糖浓度由对照组的591.5±38.2mg％分别降低到559.1±53.2,463.2±16.6和266.6±29.9mg％。在注射消炎痛10mg/kg的实验组,血清胰岛素浓度由对照组的10.5±2.7μU/ml增加到31.9±7.0μU/ml,胰高血糖素由对照组的550.0±27.0pg/ml降低到303.1±22.9pg/ml。组织学观察结果表明,消炎痛对四氧嘧啶引起的大鼠胰岛β细胞的损伤具有显著的保护作用。
This work observed the effects of indomethacin on alloxan-induced diabetic rats blood glucose, serum insulin and glucagon concentration. The results showed that: pre-subcutaneous injection of indomethacin can significantly reduce blood glucose levels in diabetic rats, and has a significant dose-effect relationship. At the dosage of 5, 10 and 15 mg / kg of indomethacin, the blood glucose concentration after 48h injection of alloxan was decreased from 591.5 ± 38.2mg% to 559.1 ± 53.2, 463.2 ± 16.6 and 266.6 ± 29.9mg% respectively in the control group. In the experimental group in which indomethacin 10 mg / kg was injected, the serum insulin concentration increased from 10.5 ± 2.7 μU / ml in the control group to 31.9 ± 7.0 μU / ml and glucagon decreased from 550.0 ± 27.0 pg / ml in the control group to 303.1 ± 22.9 pg / ml. Histological observations show that indomethacin has a significant protective effect against alloxan-induced rat pancreatic β-cell damage.