作者经长期的X 线片随访,评价了长期和短期应用13-顺维甲酸治疗角化病和囊肿性痤疮病人骨骼改变的结果。有8例角化病病人(包括1例板层鱼鳞病),口服13-顺维甲酸治疗。他们以往均未用过维甲酸治疗。在研究中,开始的剂量是1～3mg/kg/d,以后降至1mg/kg/d。最初4年中, The authors evaluated the long-term and short-term follow-up X-ray follow-up results of 13-cis retinoic acid in patients with keratoses and cystic acne. There were 8 cases of keratoses (including 1 case of lamellar ichthyosis) treated with oral 13-cis retinoic acid. They have not used retinoic acid treatment in the past. In the study, the initial dose was 1 to 3 mg/kg/d, and later decreased to 1 mg/kg/d. In the first 4 years,