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在15例体外培养的人垂体生长激素(GH)分泌瘤细胞上研究1,25-(OH)_2D_3对GH分泌的调节作用,发现14例瘤细胞的GH分泌对血清生理范围(40～80pg/ml)的1,25-(OH)_2D_3有兴奋和抑制两种反应,其中9例出现GH分泌明显的抑制反应,2例呈明显兴奋反应,3例在培养不同天分别出现兴奋和抑制不同形式的反应。1,25-(OH)_2D_3使垂体GH瘤GH分泌的抑制平均为对照的63.1±3.3％,GH分泌的增加达对照值的164.0±6.2％.本研究结果表明,血清生理范围的1,25-(OH)_2D_3对大多数体外培养的人垂体GH瘤的GH分泌有直接调节作用,这种作用包括抑制与兴奋两种,其中抑制作用更为常见。
The regulatory effect of 1,25- (OH) _2D_3 on GH secretion was studied in 15 human pituitary GH-secreting tumor cells and found that the GH secretion of 14 tumor cells had no significant effect on the serum physiological range (40-80 pg / ml) of 1,25- (OH) _2D_3 excited and inhibited two kinds of reactions, of which 9 cases showed significant GH secretion inhibition reaction was significantly excited in 2 cases, 3 cases were cultured on different days were excited and inhibited the different forms Reaction. 1,25- (OH) _2D_3 inhibited GH secretion of pituitary GH tumors averaging 63.1 ± 3.3% of the control and GH secretion increased by 164.0 ± 6.2% of the control value.The results of this study showed that the serum physiological range of 1,25 - (OH) _2D_3 has a direct regulatory effect on the GH secretion of most human pituitary GH tumors cultured in vitro. This effect includes both inhibition and excitability, of which inhibition is more common.